| Bioactivity | Thonningianin B is an antioxidant and an autophagy enhancer[1][2]. |
| Invitro | Thonningianin B 对 DPPH 自由基有较强的清除作用。34.5 μM 的 Thonningianin B 溶液可以完全清除 DPPH 自由基。在另一个实验中，Thonningianin B 的 IC50 值为 21 μM[1]。Thonningianin B (0-100 μM; 24 h) 抑制 BV-2 细胞活力，IC50 为 46.74 μM[2]。Thonningianin B (10 μM;24 h) 显著提高了 BV-2 细胞中 LC3-II/LC3-I 的比例和每个细胞平均 GFP-LC3 点数[2]。 Cell Viability Assay[2] Cell Line: |
| Name | Thonningianin B |
| CAS | 271579-12-5 |
| Formula | C35H30O17 |
| Molar Mass | 722.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ohtani II, et al. Thonningianins A and B, new antioxidants from the African medicinal herb Thonningia sanguinea. J Nat Prod. 2000 May;63(5):676-9. [2]. Zhou XG, et al. Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer's disease. Inflamm Regen. 2022 Aug 3;42(1):25. |