| Bioactivity | Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation[1]. | ||||||
| Invitro | Thiostrepton (0.01-1000 μM; 48 hours) suppresses cell viability in A2780 and HEC-1A[2]. Cell Viability Assay[2] Cell Line: | ||||||
| Name | Thiostrepton | ||||||
| CAS | 1393-48-2 | ||||||
| Formula | C72H85N19O18S5 | ||||||
| Molar Mass | 1664.89 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Thiostrepton
CAS: 1393-48-2 F: C72H85N19O18S5 W: 1664.89
Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1.FOXM1 binds to YAP/TEAD complex.YAP/TEAD/FOXM1 co
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