| Bioactivity | Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a Kiapp value of 19 nM[1]. |
| Invitro | Thiomarinol A 显示抗菌活性，对 COL IleRS, LLMR COL IleRSV588F/V631F, LLMR COL IleRSF587V/V631F, LLMR COL IleRSV588F, IleRSV588F MupA, thiomarinol-resistant COL IleRSG593D, thiomarinol-resistant COL IleRSP606S 的 MIC 值分别为 0.002, 0.08, 0.04, 0.04, 0.50, 0.02, 0.01 µM[1]。 |
| Name | Thiomarinol A |
| CAS | 146697-04-3 |
| Formula | C30H44N2O9S2 |
| Molar Mass | 640.81 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Johnson RA, et al. Inhibition of Isoleucyl-tRNA Synthetase by the Hybrid Antibiotic Thiomarinol. J Am Chem Soc. 2021 Aug 11;143(31):12003-12013. |
Thiomarinol A
CAS: 146697-04-3 F: C30H44N2O9S2 W: 640.81
Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marino
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