| Bioactivity | Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). The IC50 value for thioetheramide-PC is 2 μM at a substrate concentration of 0.5 mM.1 In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it. |
| CAS | 116457-99-9 |
| Formula | C40H83N2O5PS |
| Molar Mass | 735.14 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yu, et al. The interaction of phospholipase A2 with phospholipid analogues and inhibitors. J. Biol. Chem. 265, 2657-2664 (1990). |
Thioetheramide-PC
CAS: 116457-99-9 F: C40H83N2O5PS W: 735.14
Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secre
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