| Bioactivity | Thalidomide-NH-CH2-COOH TFA is a selective CDK9 degrader with the activity of promoting rapid degradation of CDK9. Thalidomide-NH-CH2-COOH TFA exhibits more sustained effects than traditional CDK9 inhibitors in inducing apoptosis. The conjugation strategy of Thalidomide-NH-CH2-COOH TFA enables its conversion into a more selective degrader, thereby showing new potential in anti-cancer therapy[1]. |
| CAS | 2377032-39-6 |
| Formula | C17H14F3N3O8 |
| Molar Mass | 445.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Calla M Olson, et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170. [2]. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation |
Thalidomide-NH-CH2-COOH TFA
CAS: 2377032-39-6 F: C17H14F3N3O8 W: 445.30
Thalidomide-NH-CH2-COOH TFA is a selective CDK9 degrader with the activity of promoting rapid degradation of CDK9. Thali
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