| Bioactivity | Thalidomide-NH-C10-Boc (compound S20) is a conjugate of the E3 ubiquitinase ligand Thalidomide and PROTAC Linker, which can recruit Cereblon ubiquitinase. Thalidomide-NH-C10-Boc can couple the target protein ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, Thalidomide-NH-C10-Boc can couple with the ligand EP300/CBP ligand 2 (HY-161960) to produce the PROTAC molecule dCE-2 (HY-161958)[1]. |
| CAS | 2428400-25-1 |
| Formula | C28H39N3O6 |
| Molar Mass | 513.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Structure-Based Design of CBP/EP300 Degraders: When Cooperativity Overcomes Affinity |
Thalidomide-NH-C10-Boc
CAS: 2428400-25-1 F: C28H39N3O6 W: 513.63
Thalidomide-NH-C10-Boc (compound S20) is a conjugate of the E3 ubiquitinase ligand Thalidomide and PROTAC Linker, which
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