| Bioactivity | Thalidomide-N-methylpiperazine is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-N-methylpiperazine can be used to synthesize PROTAC MLKL Degrader-2 (HY-169072) [1] to exhibit antinecroptotic activity on human cell lines and effectively degrade MLKL in the HT-29 xenograft mouse model[1]. |
| CAS | 2924858-30-8 |
| Formula | C18H20N4O4 |
| Molar Mass | 356.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li S, et al. Discovery of Covalent MLKL PROTAC Degraders via Optimization of a Theophylline Derivative Ligand for Treating Necroptosis. J Med Chem. 2024 Sep 12;67(17):15353-15372. |
Thalidomide-N-methylpiperazine
CAS: 2924858-30-8 F: C18H20N4O4 W: 356.38
Thalidomide-N-methylpiperazine is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-N-methylpiperazine can be used to sy
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