Thalidomide-5-PEG3-NH2 hydrochloride_product_DataBase

Bioactivity	Thalidomide-5-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Invitro	PROTAC 包含两个不同的配体，由一个连接体连接；一个是 E3 泛素连接酶的配体，另一个是目标蛋白的配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[2]。
Name	Thalidomide-5-PEG3-NH2 hydrochloride
Formula	C19H24ClN3O7
Molar Mass	441.86
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-995.

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