| Bioactivity | TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range[1][2]. |
| Invitro | TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells[1].TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles[2]. |
| Name | TfR-T12 |
| CAS | 344618-30-0 |
| Sequence | Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro |
| Shortening | THRPPMWSPVWP |
| Formula | C71H99N19O15S |
| Molar Mass | 1490.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
TfR-T12
CAS: 344618-30-0 F: C71H99N19O15S W: 1490.73
TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range.
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