| Bioactivity | TfR-T12 TFA is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range[1][2]. | ||||||
| Invitro | TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells[1].TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles[2]. | ||||||
| Name | TfR-T12 TFA | ||||||
| Sequence | Thr-His-Arg-Pro-Pro-Met-Trp-Ser-Pro-Val-Trp-Pro | ||||||
| Shortening | THRPPMWSPVWP | ||||||
| Formula | C73H100F3N19O17S | ||||||
| Molar Mass | 1604.75 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |