| Bioactivity | TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC50 values of 0.51, 0.46, and 0.48 μM, respectively[1]. |
| CAS | 1643444-62-5 |
| Formula | C20H12ClF2FeN2O2 |
| Molar Mass | 441.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bernkop-Schnürch, et al. "Transferrin Receptor-Mediated Cellular Uptake of Fluorinated Chlorido [N, N′-bis (salicylidene)-1, 2-phenylenediamine] iron (III) Complexes." ACS Omega (2024). |
TfR-1-IN-1
CAS: 1643444-62-5 F: C20H12ClF2FeN2O2 W: 441.62
TfR-1-IN-1 (compound C4) is an inhibitor of transferrin receptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly
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