| Bioactivity | Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. It inhibits the growth of T. brucei in vitro (IC50=30.87 μM). Tetromycin B is also cytotoxic to HEK293T kidney cells and J774.1 macrophages (IC50s=71.77 and 20.2 μM, respectively). |
| CAS | 180027-84-3 |
| Formula | C34H46O5 |
| Molar Mass | 534.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pimentel-Elardo, et al. New tetromycin derivatives with anti-trypanosomal and protease inhibitory activities. Mar. Drugs 9(10), 1682-1697 (2011). |
Tetromycin B
CAS: 180027-84-3 F: C34H46O5 W: 534.73
Tetromycin B is a cysteine protease inhibitor with Ki values of 0.62, 1.42, 32.5, and 1.59 μM for rhodesain, falcipain-
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