| Bioactivity | Tetradecylphosphonic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. |
| Invitro | Tetradecyl phosphonate 是溶血磷脂酸 1 (LPA1)、LPA2 和 LPA3 受体的泛拮抗剂。抑制 LPA 诱导的钙动员的 IC50 值分别为 10 μM、5.5 μM 和 3.1 μM。在浓度为 10 μM 时，膦酸十四烷基酯可激活过氧化物酶体增殖物激活受体 γ 报告基因构建体，与对照相比可激活 4 倍，并部分抑制自分泌运动因子，IC50 值约为 3 μM。溶血磷脂酸 (LPA) 也称为自分泌运动因子 (ATX)，是溶血磷脂酶 D 水解溶血磷脂酰胆碱形成的脂质信号分子。LPA 信号通过四种不同的 G 蛋白偶联受体，命名为 LPA1/EDG-2、LPA2/EDG-4、LPA3/EDG-7 和 LPA4/GPR23 。据报道，LPA 参与激活过氧化物酶体增殖物激活受体 γ (PPARγ) 。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Tetradecylphosphonic acid 相关抗体: |
| CAS | 4671-75-4 |
| Formula | C14H31O3P |
| Molar Mass | 278.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Durgam GG, Virag T, Walker MD, et al . Synthesis, structure activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARγ, and inhibitors of autotaxin[J]. Journal of medicinal chemistry, 2005, 48( 15): 4919-4930. [2]. Tokumura A, Majima E, Kariya Y, et al. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase[J]. Journal of Biological Chemistry, 2002, 2 77(42): 39436-3944 [3]. Noguchi K, Ishii S, Shimizu T. Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family[J]. Journal of Biological Chemistry, 2003 , 278(28): 25600-2560 [4]. McIntyre TM, Pontsler AV, Silva AR, et al. Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist[J]. Proceedings of the National Academy of Sciences, 2003, 100(1): 131-13 |
Tetradecylphosphonic acid
CAS: 4671-75-4 F: C14H31O3P W: 278.37
Tetradecylphosphonic acid is a biochemical reagent that can be used as a biological material or organic compound for lif
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