| Bioactivity | Tetraacetylphytosphingosine is a sphingolipid metabolite produced by phytosphingosine acetylation. Tetraacetylphytosphingosine exerts its inhibitory action on angiogenesis through the inhibition of MAPK activation and intracellular calcium increase[1]. Tetraacetylphytosphingosine induces apoptosis in HaCaT cells[2]. |
| Invitro | Tetraacetylphytosphingosine（TAPS；5 μM；24小时）显著降低HUVEC中VEGF诱导的趋化迁移和毛细血管样管形成。Tetraacetylphytosphingosine 可显著抑制 VEGF 诱导的蛋白水解酶产生，包括 MMP-2、尿激酶型纤溶酶原激活剂 (uPA) 和纤溶酶原激活剂抑制剂-1 (PAI-1)。Tetraacetylphytosphingosine 还可抑制 VEGF 诱导的 p42/44 细胞外信号调节激酶和 c-JNK 磷酸化[1]。此外，Tetraacetylphytosphingosine 可消除 VEGF 诱导的细胞内钙离子升高[1]。在 HaCaT 细胞中，Tetraacetylphytosphingosine 联合治疗通过调节促凋亡 Bax 和抗凋亡 Bcl-2 的水平，协同增加 UVB 诱导的细胞凋亡水平，这是通过激活 caspase 实现的[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Tetraacetylphytosphingosine 相关抗体: Western Blot Analysis[1] Cell Line: |
| CAS | 13018-48-9 |
| Formula | C26H47NO7 |
| Molar Mass | 485.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yoo Bin Kwon, et al. Anti-angiogenic effect of tetraacetyl-phytosphingosine. Exp Dermatol. 2007 Apr;16(4):311-7. [2]. H J Kim, et al. Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative, tetraacetyl phytosphingosine in HaCaT cell and mouse skin. Apoptosis. 2004 Jul;9(4):449-56. |
Tetraacetylphytosphingosine
CAS: 13018-48-9 F: C26H47NO7 W: 485.65
Tetraacetylphytosphingosine is a sphingolipid metabolite produced by phytosphingosine acetylation. Tetraacetylphytosphin
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