| Bioactivity | Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells[1][2]. | ||||||||||||
| Invitro | Tesmilifene may modulate the effects of 12(S)HETE in cancer cells, and indirectly, influence the susceptibility of cellular DNA to chemotherapy[1]. | ||||||||||||
| In Vivo | Tesmilifene (DPPE, 20 mg/kg (s.c.) and 20 μg (icv in 5 μL)) potentiated seizures induced by both convulsants[2]. Animal Model: | ||||||||||||
| Name | Tesmilifene fumarate | ||||||||||||
| CAS | 1185241-83-1 | ||||||||||||
| Formula | C23H29NO5 | ||||||||||||
| Molar Mass | 399.48 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Mark Vincent, et al. Tesmilifene may enhance breast cancer chemotherapy by killing a clone of aggressive, multi-drug resistant cells through its action on the p-glycoprotein pump. Med Hypotheses. 2006;66(4):715-31. [2]. G Sturman, et al. Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice Agents Actions. 1994 Jun;41 Spec No:C68-9. |
Tesmilifene fumarate
CAS: 1185241-83-1 F: C23H29NO5 W: 399.48
Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to off
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.