| Bioactivity | Teprasiran (QPI-1002) is a small interfering RNA that temporarily inhibits p53-mediated cell death that underlies acute kidney injury (AKI)[1]. |
| Invitro | Teprasiran is a synthetic, chemically stabilized small interfering RNA (siRNA) acting through RNA interference, which temporarily inhibits p53 expression for ≈48 to 72 hours[1]. |
| Name | Teprasiran |
| CAS | 1231737-88-4 |
| Sequence | RNA, (G-Am-G-Am-A-Um-A-Um-U-Um-C-Am-C-Cm-C-Um-U-Cm-A), complex with RNA (Um-G-Am-A-Gm-G-Gm-U-Gm-A-Am-A-Um-A-Um-U-Cm-U-Cm) (1:1) |
| Molar Mass | 12320.00 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Matthias Thielmann, et al. Teprasiran, a Small Interfering RNA, for the Prevention of Acute Kidney Injury in High-Risk Patients Undergoing Cardiac Surgery: A Randomized Clinical Study. Circulation. 2021;144:1133-1144. |