| Bioactivity | Tenofovir diphosphate (TFV-DP) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase (RT)[1]. |
| Target | DNA polymerases; HIV-1 reverse transcriptase |
| Invitro | Tenofovir diphosphate acts as an inhibitor of DNA pol. Tenofovir-diphosphate is a weak inhibitor of DNA polymerases (pol) α, δ, and ɛ, with values for the Ki for PMPApp (PMPAppKi) relative to the Km for dATP (dATPKm) of 10.2, 10.2, and 15.6, respectively[1]. |
| Name | Tenofovir diphosphate |
| CAS | 166403-66-3 |
| Formula | C9H16N5O10P3 |
| Molar Mass | 447.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gabriel Birkus, et al. Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases Alpha, Delta, and epsilon. Antimicrob Agents Chemother. 2002 May;46(5):1610-3. |
Tenofovir diphosphate
CAS: 166403-66-3 F: C9H16N5O10P3 W: 447.17
Tenofovir diphosphate (TFV-DP) is a competitive DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV
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