| Bioactivity | Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, leading to DNA damage responses. Telomeric G4s ligand 1 induces apoptosis and evokes immunogenic cell death (ICD) in tumor cells[1]. |
| Invitro | Telomeric G4s ligand 1（化合物 R1；1-4 μM；24 小时）可稳定 G4 并在 MDA-MB-231 细胞的端粒区域诱导 R 环结构，从而引发 DNA 损伤反应、G2/M 期细胞周期停滞、细胞凋亡和抗增殖[1]。Telomeric G4s ligand 1 可引发肿瘤细胞的免疫原性细胞死亡 (ICD)，从而促进骨髓衍生树突状细胞 (BMDC) 的成熟[1]。MDA-MB-231 cells1 μM, 2 μM, 4 μM 24 hIncreased the levels of DNA damage-related proteins, such as γH2AX and replication protein A subunit. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Telomeric G4s ligand 1 相关抗体: Cell Cycle Analysis[1] Cell Line: |
| In Vivo | Telomeric G4s ligand 1 (compound R1; 10 mg/kg; ip; every other day for 14 days) exhibits a significant decrease in tumor burden through the immunomodulatory effects, including the increase of CD4+ and CD8+ T cells in tumors and cytokine levels in sera in breast cancer mouse model[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C31H37F3N6 |
| Molar Mass | 550.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jia-Xin Wang, et al. Novel quinoxaline analogs as telomeric G-quadruplex ligands exert antitumor effects related to enhanced immunomodulation. Eur J Med Chem. 2024 Aug 5:274:116536. |
Telomeric G4s ligand 1
CAS: F: C31H37F3N6 W: 550.66
Telomeric G4s ligand 1 is a telomeric G-quadruplex ligand that stabilizes telomeric G4 and induces R-loop formation, lea
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