| Bioactivity | Telithromycin (HMR3647) is a novel ketolide antibiotic that structurally resembles macrolides. Telithromycin belongs to the ketolide family that is characterized by a keto group at position 3 of the macrolide ring and is active against bacteria causing community-acquired pneumonia, acute exacerbation of chronic bronchitis, and acute sinusitis. Telithromycin also has similar immunomodulatory effects as macrolides. Telithromycin can be used for the research of respiratory infections including bronchial asthma[1][2]. | ||||||||||||
| Invitro | Telithromycin (HMR3647) (0-50 μg/mL, 30 min) suppress C. pneumoniae-induced MUC5AC production[1].Telithromycin (0-50 μg/mL, 30 min) suppress C. pneumoniae-induced NF-kB activation[1].Telithromycin (10 mg/mL, 1 h) inhibits the production of MIP-2 and TNF-α in a dose-dependent manner by LPS-stimulated RAW 264.7 macrophages[2].Telithromycin (10 mg/mL, 1 h) inhibits NF-kB activation, increases apoptosis in cell and decreases the LPS-induced influx of neutrophils in BAL fluid[2]. RT-PCR[1] Cell Line: | ||||||||||||
| Name | Telithromycin | ||||||||||||
| CAS | 191114-48-4 | ||||||||||||
| Formula | C43H65N5O10 | ||||||||||||
| Molar Mass | 812.00 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
Telithromycin
CAS: 191114-48-4 F: C43H65N5O10 W: 812.00
Telithromycin (HMR3647) is a novel ketolide antibiotic that structurally resembles macrolides. Telithromycin belongs to
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.