| Bioactivity | Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific inhibitor of protein phosphatases 1 and 2A and induces contraction of smooth muscle under Ca2+-free conditions, with Kiapp values of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively[1][2]. | |||||||||
| Invitro | MTC cell growth is inhibited in a dose-dependent manner by Tautomycin (0-1000 nM, 48 hours)[2].NE markers ASCL1 and CgA in human MTC cells are decreased in a dose-dependent manner by Tautomycin (0-1000 nM, 48 hours)[2]. Cell Proliferation Assay[2] Cell Line: | |||||||||
| Name | Tautomycin | |||||||||
| CAS | 109946-35-2 | |||||||||
| Formula | C41H66O13 | |||||||||
| Molar Mass | 766.96 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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Tautomycin
CAS: 109946-35-2 F: C41H66O13 W: 766.96
Tautomycin, an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus, is a potent and specific in
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