| Bioactivity | Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. | ||||||||||||
| Invitro | Tauroursodeoxycholate (TUDCA) suppresses both viability and migration of vascular smooth muscle cells (VSMCs) through inhibition of ERK phosphorylation, by induction of mitogen-activated protein kinase phosphatase-1 (MKP-1) via PKCα. Tauroursodeoxycholate inhibits both the proliferation and migration of VSMCs via inhibition of ERK, through Ca2+-dependent PKCα translocation. Tauroursodeoxycholate prevents platelet-derived growth factor (PDGF) and vascular injury-induced MMP-9 expression. The knock-down of MKP-1 using specific si-RNA restores the reduced VSMC viability by Tauroursodeoxycholate (200 μM), which suggests that anti-proliferative effect of Tauroursodeoxycholate depended on the MKP-1 expression[1]. | ||||||||||||
| Name | Tauroursodeoxycholate | ||||||||||||
| CAS | 14605-22-2 | ||||||||||||
| Formula | C26H45NO6S | ||||||||||||
| Molar Mass | 499.70 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Tauroursodeoxycholate
CAS: 14605-22-2 F: C26H45NO6S W: 499.70
Tauroursodeoxycholate (Tauroursodeoxycholic acid)is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholat
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