| Bioactivity | Taurolithocholic acid is a bile acid that has the activity of increasing cell viability, inducing the S phase of the cell cycle, and promoting DNA synthesis in a concentration-dependent manner in the intrahepatic cholangiocarcinoma cell line RMCCA-1. It can also increase the phosphorylation of EGFR and ERK 1/2 and the expression of cyclin D1 in RMCCA-1 cells, and its induced RMCCA-1 cell growth can be inhibited by specific antagonists and inhibitors. |
| CAS | 516-90-5 |
| Formula | C26H45NO5S |
| Molar Mass | 483.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Taurolithocholic acid promotes intrahepatic cholangiocarcinoma cell growth via muscarinic acetylcholine receptor and EGFR/ERK1/2 signaling pathway [2]. Effects of sulfation of taurolithocholic and glycolithocholic acids on their intestinal transport |
Taurolithocholic acid
CAS: 516-90-5 F: C26H45NO5S W: 483.70
Taurolithocholic acid is a bile acid that has the activity of increasing cell viability, inducing the S phase of the cel
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