| Bioactivity | Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD)[1][2][3][4]. |
| Invitro | Taurodeoxycholic acid (50 μM，100 μM；4 h) 增加原代人肝细胞中寡核体 DNA 切割和细胞核凋亡[1]。Taurodeoxycholic acid (400 μM；18-24 h) 在人肝来源的 Huh7 细胞中增加 DNA 碎片和 PARP 切割，诱导凋亡[2]。 |
| Name | Taurodeoxycholic acid |
| CAS | 516-50-7 |
| Formula | C26H45NO6S |
| Molar Mass | 499.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
Taurodeoxycholic acid
CAS: 516-50-7 F: C26H45NO6S W: 499.70
Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxyc
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