| Bioactivity | Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Taurodeoxycholic acid sodium hydrate activates the S1PR2 pathway in addition to the TGR5 pathway[1]. |
| Invitro | The median plasma concentration of Taurodeoxycholate is 33.9 nM in healthy individuals[1].Taurodeoxycholate inhibits the binding of N-3H-methylscopolamine to the M3 muscarinic receptor of acetylcholine with an IC50 of 170 µM[1].Taurodeoxycholate (0.05-1.00 mM; 1-6 days) stimulates intestinal epithelial cell proliferation[2].Taurodeoxycholate (0.05-1.00 mM; 24 h) induces a significant increase in S-phase concentration and a significant decrease in G1-phase concentration of the cell cycle, increases c-myc protein and mRNA expression in IEC-6 cells[2]. Cell Proliferation Assay[2] Cell Line: |
| Name | Taurodeoxycholic acid sodium hydrate |
| CAS | 110026-03-4 |
| Formula | C26H46NNaO7S |
| Molar Mass | 539.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Taurodeoxycholic acid sodium hydrate
CAS: 110026-03-4 F: C26H46NNaO7S W: 539.70
Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant m
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