| Bioactivity | Targapremir-210 (TGP-210) is a potent and selective miR-210 (miRNA-210, microRNA-210) inhibitor. Targapremir-210 inhibits pre-miR-210 processing with high binding affinity (Kd~200 nM)[1]. | ||||||||||||
| Invitro | Targapremir-210 decreases mature miR-210 levels in MDA-MB-231 cells cultured under hypoxic conditions, with an IC50 of ∼200 nM[1].Targapremir-210 (200 nM) induces MDA-MB-231 cells apoptosis is selective for the hypoxic environment. Targapremir-210 induces cells apoptosis under hypoxic conditions and does not induce apoptosis in MDA-MB-231 cells cultured in normoxia[1]. | ||||||||||||
| Name | Targapremir-210 | ||||||||||||
| CAS | 1049722-30-6 | ||||||||||||
| Formula | C32H36N10O2 | ||||||||||||
| Molar Mass | 592.69 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Targapremir-210
CAS: 1049722-30-6 F: C32H36N10O2 W: 592.69
Targapremir-210 (TGP-210) is a potent and selective miR-210 (miRNA-210, microRNA-210) inhibitor. Targapremir-210 inhibit
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