| Bioactivity | Tankyrase-IN-5 (Compound 30f), an analogue of MSC2504877 (HY-123851), is a tankyrase TNKS1 and TNKS2 inhibitor with IC50s of 2.3 nM and 7.9 nM, respectively[1]. |
| Target | IC50: 2.3 nM (TNKS1), 7.9 nM (TNKS2), 1900 nM (PARP1) |
| Name | Tankyrase-IN-5 |
| CAS | 1460285-69-1 |
| Formula | C17H18N2O2 |
| Molar Mass | 282.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Buchstaller HP, et al. Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J Med Chem. 2021 Jul 22;64(14):10371-10392. |
Tankyrase-IN-5
CAS: 1460285-69-1 F: C17H18N2O2 W: 282.34
Tankyrase-IN-5 (Compound 30f), an analogue of MSC2504877 (HY-123851), is a tankyrase TNKS1 and TNKS2 inhibitor with IC50
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