| Bioactivity | Tamoxifen-PEG-Clozapine is an estrogen receptor α (ERα) PROTAC degrader. Tamoxifen-PEG-Clozapine degrades ERα via a ubiquitin-proteasome system that uses the ubiquitin protein ligase E3 component N-recognin 5. Tamoxifen-PEG-Clozapine can be used for the research of cancer[1]. (Pink: ERα inhibitor (HY-W271653); Black: linker (HY-168870); Blue: CRBN Ligand (HY-G0021)) |
| Formula | C54H63ClN6O7 |
| Molar Mass | 943.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Takano R, Ohoka N, Kurohara T, et al. Clozapine as an E3 Ligand for PROTAC Technology[J]. ACS Medicinal Chemistry Letters, 2025. |
Tamoxifen-PEG-Clozapine
CAS: F: C54H63ClN6O7 W: 943.57
Tamoxifen-PEG-Clozapine is an estrogen receptor α (ERα) PROTAC degrader. Tamoxifen-PEG-Clozapine degrades ERα via a u
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