| Bioactivity | TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively. | |||||||||
| Target | IC50: 0.4 nM (Simian chymase), 0.7 nM (Human chymase) | |||||||||
| In Vivo | TY-51469 shows 100% stability in rat plasma at 40°C for as long as 1 hour[1]. TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice[2]. | |||||||||
| Name | TY-51469 | |||||||||
| CAS | 603987-59-3 | |||||||||
| Formula | C20H15FN2O6S4 | |||||||||
| Molar Mass | 526.60 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Takato H, et al. The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice. Expert Opinion on Therapeutic Targets Volume 15, 2011 - Issue 4. |