| Bioactivity | TX-1918 is an inhibitor for eukaryotic elongation factor 2 kinase (eEF2-K) and Src kinase with IC50 of 0.44 and 4.4 μM, respectively. TX-1918 exhibits cytotoxicity in cell HepG2 and HCT116, with IC50 of 2.07 and 230 μM, respectively. TX-1918 inhibits the C-terminal domain of HIV-1 CA (CA CTD) with IC50 of 3.81 μM, and inhibits the viral replication with IC50 of 15.16 μM[1][2]. |
| Target | IC50: 44 μM (PKA), 44 μM (PKC), 4.4 μM (Src), 0.44 μM (eEF2 kinase) |
| CAS | 503473-32-3 |
| Formula | C14H12O3 |
| Molar Mass | 228.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hori H, et al., TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioorg Med Chem. 2002 Oct;10(10):3257-65. [2]. Zhang DW, et al., A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-Terminal domain of capsid. Antiviral Res. 2019 Sep;169:104544. |