| Bioactivity | TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ[1]. | ||||||||||||
| Target | pKi: 6.69 (FFA2) | ||||||||||||
| Invitro | TUG-1375 exhibits pEC50 of 7.11 in the cAMP FFA2 assay, also active on murine FFA2 orthologue (pEC50, 6.44 ± 0.13 in the cAMP assay)[1]. | ||||||||||||
| Name | TUG-1375 | ||||||||||||
| CAS | 2247372-59-2 | ||||||||||||
| Formula | C22H19ClN2O4S | ||||||||||||
| Molar Mass | 442.92 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Hansen AH, et al. Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem. 2018 Nov 8;61(21):9534-9550. |
TUG-1375
CAS: 2247372-59-2 F: C22H19ClN2O4S W: 442.92
TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pKi of 6.69. TUG-1375 is inactive on FFA3, FFA
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