| Bioactivity | TTK/PLK1-IN-1 (Formula I) is the inhibitor for threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1) with IC50 of 7 nM and 72 nM. TTK/PLK1-IN-1 regulates spindle assembly checkpoint (SAC), and exhibits antitumor efficacy against TNBC[1]. |
| Target | IC50: 7 nM (threonine tyrosine kinase); 72 nM (polo-like kinase 1) |
| CAS | 1817791-70-0 |
| Formula | C30H33N7O2 |
| Molar Mass | 523.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lane H, et al., Pharmaceutical combinations for use in the treatment of neoplastic diseases. WO2023167549. |
TTK/PLK1-IN-1
CAS: 1817791-70-0 F: C30H33N7O2 W: 523.63
TTK/PLK1-IN-1 (Formula I) is the inhibitor for threonine tyrosine kinase (TTK) and polo-like kinase 1 (PLK1) with IC50 o
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