| Bioactivity | TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM. TS-24 exhibits radiosensitizing activity in wild type breast cancer susceptibility gene 1 (BRCA1) and in TNBC xenograft mice model, through induction of apoptosis[1]. |
| Invitro | TS-24 (0-1 μM，24 h) 抑制 HEK293T 细胞中乳腺癌易感基因 1 (BRCA1) 的降解，从而诱导放射增敏活性[1]。TS-24 (0-10 μM，24 h) 抑制 MDA-MB-231 细胞迁移[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> TS-24 相关抗体: Cell Viability Assay[1] Cell Line: |
| In Vivo | TS-24 (1 mg/kg，腹腔注射，一周 3 次，共 6 周) 可抑制 TNBC 异种移植小鼠模型中的肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 1563260-97-8 |
| Formula | C20H15NO2 |
| Molar Mass | 301.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Choi E, et al., Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cells. Cancer Sci. 2024 Apr 13. |