| Bioactivity | TS 155-2 (JBIR 100), an antimicrobial agent, is a Bafilomycin analogue and an antibiotic. TS 155-2 can be isolated from a culture of Streptomyces sp. TS 155-2 inhibits V-ATPase activity. V-ATPase is correlated with an increasing number of diseases such as osteopetrosis, male infertility and renal acidosis[1][2]. |
| Invitro | JBIR 100 shows cytotoxic effect against HeLa cells (IC50: 72.6 nM) at 48 h[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> TS 155-2 相关抗体: |
| CAS | 1314486-37-7 |
| Formula | C39H60O11 |
| Molar Mass | 704.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ueda JY, et al. A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species. J Antibiot (Tokyo). 2010 Oct;63(10):627-9. [2]. Molloy EM, et al. Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products. Bioorg Med Chem. 2016 Dec 15;24(24):6276-6290. |