| Bioactivity | TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1]. | |||||||||
| Target | EC50: 60 nM (hTRPV4 hTRPV4 Ca2+) | |||||||||
| Invitro | TRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels[1]. | |||||||||
| Name | TRPV4 agonist-1 free base | |||||||||
| CAS | 2314467-59-7 | |||||||||
| Formula | C25H22F2N4O2 | |||||||||
| Molar Mass | 448.46 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J |
TRPV4 agonist-1 free base
CAS: 2314467-59-7 F: C25H22F2N4O2 W: 448.46
TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTR
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