| Bioactivity | TRPV2-selective blocker 1 (compound IV2-1) is a selective TRPV2 channel blocker with an IC50 of 6.3 μM. TRPV2-selective blocker 1 does not affect TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 also inhibits TRPV2-mediated Ca2+ influx in macrophages, and inhibits macrophage phagocytosis[1]. |
| Name | TRPV2-selective blocker 1 |
| CAS | 2242724-49-6 |
| Formula | C15H18OS2 |
| Molar Mass | 278.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rick Raudszus, et al. Pharmacological inhibition of TRPV2 attenuates phagocytosis and lipopolysaccharide-induced migration of primary macrophages. Br J Pharmacol. 2023 Nov;180(21):2736-2749. |
TRPV2-selective blocker 1
CAS: 2242724-49-6 F: C15H18OS2 W: 278.43
TRPV2-selective blocker 1 (compound IV2-1) is a selective TRPV2 channel blocker with an IC50 of 6.3 μM. TRPV2-select
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