| Bioactivity | TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arrest and apoptosis, decreases the migration of MCF-7 and BGC-823 cells. TRPM7-IN-1 decreases vimentin expression and increases E-cadherin expression. TRPM7-IN-1 potentially reduces the TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway. TRPM7-IN-1 is a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function[1]. |
| CAS | 1909225-07-5 |
| Formula | C23H25N5O3 |
| Molar Mass | 419.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xiaoding Zhang, et al. Novel benzoylurea derivative decreases TRPM7 channel function and inhibits cancer cells migration. Channels (Austin). 2024 Dec;18(1):2396339. |
TRPM7-IN-1
CAS: 1909225-07-5 F: C23H25N5O3 W: 419.48
TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arre
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