| Bioactivity | TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca2+ concentrations ([Ca2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals[1]. | ||||||||||||
| Target | EC50: 2.37 μM (TRPC6-expressing HEK293 cells) | ||||||||||||
| Name | TRPC6-PAM-C20 | ||||||||||||
| CAS | 667427-75-0 | ||||||||||||
| Formula | C22H21NO4 | ||||||||||||
| Molar Mass | 363.41 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. S Häfner, et al. Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels. Cell Calcium. 2019 Mar;78:26-34. |
TRPC6-PAM-C20
CAS: 667427-75-0 F: C22H21NO4 W: 363.41
TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer o
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