| Bioactivity | TRPC6-IN-3 (compound 17) is a potent, orally active transient receptor potential C6 ion channel (TRPC6) inhibitor. TRPC6-IN-3 modulates not only intracellular calcium concentration, but also membrane potential by modulating the flux of cations including calcium and sodium ions. TRPC6-IN-3 can be used in research of respiratory system[1]. | |||||||||
| In Vivo | TRPC6-IN-3 (compound 17; 1-10 mg/kg; p.o.; orally 12 h and 2 h before LPS challenge; LPS-induced mice) inhibits LPS-induced vascular leakage and inhibits accumulation of Broncho-Alveolar-Lavage protein (BALF protein) in a mouse model[1].TRPC6-IN-3 (3 mg/kg; p.o.; daily, for 4 d; H1N1-induced mice) reduces H1N1-induced vascular leakage in a mouse model[1]. Animal Model: | |||||||||
| Name | TRPC6-IN-3 | |||||||||
| CAS | 2311863-36-0 | |||||||||
| Formula | C22H22FN5O3 | |||||||||
| Molar Mass | 423.44 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Thierry B, et, al. Inhibitors of TRPC6 for treating respiratory conditions. WO2021209510. |
TRPC6-IN-3
CAS: 2311863-36-0 F: C22H22FN5O3 W: 423.44
TRPC6-IN-3 (compound 17) is a potent, orally active transient receptor potential C6 ion channel (TRPC6) inhibitor. TRPC6
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