TRPC5-IN-4_product_DataBase

Bioactivity	TRPC5-IN-4 is potent and safe TRPC inhibitor with IC50 value of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively. TRPC5-IN-4 shows no damage on the cellular component of liver and kidney. TRPC5-IN-4 can be used for the research of chronic kidney disease (CKD)[1].
Invitro	TRPC5-IN-4 (compound 16 g) (0.003-3 μM; 0-1000 seconds) significantly changes intracellular Ca2+ concentration in TRPC4- and TRPC5-HEK293 cells in a dose-dependent manner, and shows very weak inhibitory activity on the TRPC3 channel, no inhibitory effect on TRPC6 and TRPC7 channels[1].TRPC5-IN-4 (1 and 10 μM; 24 hours) does not reduce the liver and kidney cells viability[1].TRPC5-IN-4 (0.1, 0.3, 1, 3 μM; 30 minutes) concentration-dependently reduces the PS-induced podocyte rearrangement in MPC5 cells[1]. Cell Viability Assay Cell Line:
Name	TRPC5-IN-4
CAS	2762315-39-7
Formula	C18H11ClF4N4O3
Molar Mass	442.75
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhang Z, Chen L, Tian H, et al. Discovery of pyrroledione analogs as potent transient receptor potential canonical channel 5 inhibitors. Bioorg Med Chem Lett. 2022;61:128612.

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