| Bioactivity | TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects[1][2]. |
| Invitro | TRIM is a relatively weak inhibitor of eNOS (IC50, 1057.5 µM)[1]. |
| Name | TRIM |
| CAS | 25371-96-4 |
| Formula | C10H7F3N2 |
| Molar Mass | 212.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Handy RL, et al. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol. 1995;116(5):2349-2350. [2]. Volke V, et al. Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behav Brain Res. 2003;140(1-2):141-147. |