| Bioactivity | TREM2 agonist-2 (I-192) is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50<0.05 μM)[1]. |
| Invitro | TREM2 agonist-2 (0-100 μM; 16 h) treatment activates hTREM2 in HEK293 cell[1]. Cell Viability Assay[1] Cell Line: |
| In Vivo | TREM2 agonist-2 (oral gavage; 50 mg/kg; twice daily; one day) finds TREM2 target engagement on microglia[1]. Animal Model: |
| Name | TREM2 agonist-2 |
| CAS | 2738485-98-6 |
| Formula | C24H23ClFN5O |
| Molar Mass | 451.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lara C. CZABANIUK, et al. Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use. WO2021226629A1. |
TREM2 agonist-2
CAS: 2738485-98-6 F: C24H23ClFN5O W: 451.92
TREM2 agonist-2 (I-192) is an orally active triggering receptor expressed on myeloid cells 2 (TREM2) agonist (EC50
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