| Bioactivity | TRAP1-IN-2 (compound 36) is a selective TRAP1 client protein degrader, while TRAP1-IN-2 is useless for Hsp90-cytosolic clients. TRAP1-IN-2 also inhibits OXPHOS, alters cellular metabolism towards glycolysis. TRAP1-IN-2 disrupts TRAP1 tetramer stability, and disrupts the mitochondrial membrane potential[1]. |
| Target | TRAP1 |
| Name | TRAP1-IN-2 |
| Formula | C46H42F6N2O5P2 |
| Molar Mass | 878.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Merfeld T, et al. Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes. Eur J Med Chem. 2023 Oct 5;258:115531. |