| Bioactivity | TRAP-1 (XJZ-06-462) is ap53 transcriptional activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. TRAP-1 rapidly upregulates p21 and other p53 target genes in pancreatic cell lines with p53Y220C. TRAP-1 inhibits cell proliferation, with IC50 values of 3.94 and 0.531 μM in BxPC-3 and A549 cells, respectively. TRAP-1 regulates autophagy in lung cancer cells and offers protective effects against oxidative stress and cell apoptosis[1][2][3]. |
| Formula | C57H66ClF3N11O3PS |
| Molar Mass | 1108.69 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xijun Zhu, et al. Activating p53Y220C with a Mutant-Specific Small Molecule. bioRxiv. 2024 Oct 28:2024.10.23.619961. [2]. N Montesano Gesualdi, et al. Tumor necrosis factor-associated protein 1 (TRAP-1) protects cells from oxidative stress and apoptosis. Stress. 2007 Nov;10(4):342-50. [3]. Inês A Barbosa, et al. TRAP1 regulates autophagy in lung cancer cells. Eur J Clin Invest. 2018 Apr;48(4). |