| Bioactivity | TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1[1]. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques[2]. | ||||||||||||
| Target | CD40-TRAF6 interaction; NF-κB | ||||||||||||
| Name | TRAF-STOP inhibitor 6877002 | ||||||||||||
| CAS | 433249-94-6 | ||||||||||||
| Formula | C17H17NO | ||||||||||||
| Molar Mass | 251.32 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Seijkens TTP, et al. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542. |
TRAF-STOP inhibitor 6877002
CAS: 433249-94-6 F: C17H17NO W: 251.32
TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of
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