| Bioactivity | TPN729 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729 affects erectile function and it can be used for the research of erectile dysfunction[1]. |
| In Vivo | TPN729 (1.25，2.5，5.0 mg/kg；1 次) 在所有时间点 5.0 mg/kg 剂量增加海绵内压/血压比值 (ICP/BP)，在 2.5 mg/kg 剂量下 75，90，105 和 120 分钟时增加海绵内压/血压比[1]。TPN729 (5.0 μg/kg；静脉注射，1 次) 显著升高公比格犬的海绵内压和海绵内压/血压比[1]。 Animal Model: |
| Name | TPN729 |
| CAS | 936951-20-1 |
| Formula | C25H36N6O4S |
| Molar Mass | 516.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang Z, et al. The selectivity and potency of the new PDE5 inhibitor TPN729MA. J Sex Med. 2013 Nov;10(11):2790-7. |