| Bioactivity | TPH1-IN-1 (compound 40) is a xanthine derivative and an inhibitor of tryptophan hydroxylase TPH1 (IC50: 110.1 nM). TPH1-IN-1 has good in vitro activity and liver microsome stability, and effectively inhibits adipocyte differentiation of T3-L1 cells[1]. |
| Target | IC50: 110.1 nM (TPH1) |
| Name | TPH1-IN-1 |
| Formula | C21H18N6O4S |
| Molar Mass | 450.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yoon J, et al. Synthesis and biological evaluation of xanthine derivatives with phenacyl group as tryptophan hydroxylase 1 (TPH1) inhibitors for obesity and fatty liver disease. Bioorg Med Chem Lett. 2023 Oct 1;94:129461.. . |