| Bioactivity | TP0556351 is a potent and selective matrix metalloproteinase-2 (MMP2) inhibitor with an IC50 value of 0.2 nM. TP0556351 reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model. TP0556351 can be used for researching idiopathic pulmonary fibrosis (IPF)[1]. |
| In Vivo | TP0556351 (0.03, 0.1, 0.3, or 1 mg/kg/day; SC, for 14 days) reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model[1]. |
| Name | TP0556351 |
| Formula | C50H70N10O16 |
| Molar Mass | 1067.15 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Takeuchi T, et al. Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem. 2022 Jun 23;65(12):8493-8510. |