| Bioactivity | TP-DEA2, a predictable-release Triptolide (HY-32735) prodrug, block Bleomycin-induced pulmonary fibrosis and inflammation. TP-DEA2 significantly inhibits α-SMA production[1]. |
| Invitro | TP-DEA2能够在不依赖酶的情况下，自主转化为三萜类 (Triptolide, TP)[1]。TP-DEA2还可抑制转化生长因子β1（TGF-β1）诱导的解整合素和金属蛋白酶10 (ADAM 10) 的表达，降低成纤维细胞中α-SMA的分泌[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> TP-DEA2 相关抗体: |
| Formula | C25H34N2O7 |
| Molar Mass | 474.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yuhan Chen, et al. Water-soluble and predictable-release triptolide prodrugs block bleomycin-induced pulmonary fibrosis in mice. Eur J Med Chem. 2024 Sep 6:279:116839. |