| Bioactivity | TP-030-1 is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM and inhibits mRIPK1 with an IC50 value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases[1]. |
| Invitro | TP-030-1 inhibits HT29 necroptosis with an IC50 value of 18 nM[1]. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM[1].TP-030-1 inhibits mRIPK1 with an IC50 value of 4.2 μM[1]. |
| Name | TP-030-1 |
| CAS | 2095514-75-1 |
| Formula | C23H22N4O3 |
| Molar Mass | 402.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Msato Yoshikawa, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships. J. Med. Chem. 2018, 61, 6, 2384–2409. |
TP-030-1
CAS: 2095514-75-1 F: C23H22N4O3 W: 402.45
TP-030-1 is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM and inhibits mRIPK1 with an IC50 v
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