TNKS1/2-IN-2

CAS: 1498300-35-8 F: C26H24F3N3O4 W: 499.48

TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and

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Bioactivity	TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer[1].
Target	IC50: 4 nM (TNK1); 63 nM (TNK2); 39.5 nM (A549 cell); 12.8 nM (H292 cell).
Name	TNKS1/2-IN-2
CAS	1498300-35-8
Formula	C26H24F3N3O4
Molar Mass	499.48
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Qin D,et al. Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors. ACS Med Chem Lett. 2021 May 13;12(6):1005-1010.